Multi-Year Research Grants and Personnel Awards for the term of July 1, 2010 to June 30, 2011

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The Heart and Stroke Foundation of Ontario is pleased to announce confirmation of budget commitment on existing multi-year grants-in-aid and personnel awards as indicated below. An official letter will also be sent to all grant recipients shortly. For those awards identified as "pending", funding is encumbered until additional information is provided. 

Additionally, for projects that were identified as being "applied" or "clinically oriented" in the September 2008 competition, funding is encumbered pending receipt and approval of the May 15, 2010 Progress Report. For all other awards, please refer to your award letter for details.  
 
September 2009 Competition Funding Decisions
 
The funding decisions for the September 2009 competition will be announced by March 15, 2010 on the national website www.hsf.ca/research.
  • Adams, Michael A. (Queen's University)
    Antihypertensive treatment strategies in the management of sexual dysfunction
    2008, Renewal,  $100 823
     
  • Adeli, Khosrow (Hospital for Sick Children)
    Molecular mechanisms of hepatic VLDL overproduction in insulin resistance
    2007, Renewal  (Pending), $143 012
  • Adeli, Khosrow (Hospital for Sick Children)
    Molecular mechanisms of apolipoprotein B degradation
    2009, Renewal, $135 422
  • Alter, David A. (St. Michael's Hospital)
    Cardiovascular treatment & outcomes disparities among high-risk populations
    2006, Career Investigator, $87 950
  • Andrew, Robert David (Queen's University)
    Mechanisms that drive acute neuronal swelling and dysfunction in stroke
    2009, Renewal,  $84 921
  • Assini, Julia (University of Western Ontario)
    Prevention of dyslipidemia and atherosclerosis by the citrus flaveonoid, nobiletin
    2009, Master’s Studentship (Pending), $18 500
  • Austin, Peter C. (Sunnybrook Health Sciences Centre)
    Statistical methods for cardiovascular research
    2008, Career Investigator, $87 950
  • Austin, Richard C. (McMaster University)
    Role of endoplasmic reticulum stress in atherothrombotic disease
    2006, Career Investigator, $87 950
     
  • Austin, Richard C. (McMaster University)
    Contributions of the unfolded protein response pathway to adipogenesis and obesity
    2008, New Annual, $79 234
  • Austin, Richard C. (McMaster University)
    Identification and characterization of novel and therapeutic strategies that decrease atherothrombotic disease
    2008, Program (Pending), $250 000
  • Backx, Peter H. (University Health Network)
    Transcriptional regulation of cardiac transient outward K+ currents and function in heart
    2008, Renewal,  $142 096
  • Backx, Peter H. (University of Toronto)
    Studies into molecular mechanisms of cardiovascular disease
    2009, Career Investigator, $87 950
  • Beanlands, Rob S. B. (University of Ottawa Heart Institute)
    Metabolism, energetics and neurohormonal signaling and their response to therapy in dysfunctional myocardium
    2008, Career Investigator, $87 950
  • Beanlands, Rob S. B. (University of Ottawa Heart Institute)
    Elucidation of metabolic and cellular function alterations in dysfunctional myocardium and their response to therapy
    2007, Program (Pending),$249 989
  • Beattie, William S. (University Health Network)
    The ENIGMA-II trial. Nitrous oxide anaesthesia and cardiac morbidity after major surgery: a randomized controlled trial
    2009, New Annual (Pending), $80 000
  • Beca, Bogdan Mihai (University of Toronto)
    High-throughput screening of heart valve tissue engineering systems
    2009, Master’s Studentship (Pending), $18 500
  • Bendeck, Michelle P. (University of Toronto)
    Cadherins and regulation of smooth muscle cell function
    2007, Renewal  (Pending), $126 995
  • Bendeck, Michelle P. (University of Toronto)
    Discoidin domain receptors in atherosclerosis
    2009, Renewal,  $140 500
  • Bolz, Steffen-Sebastian (University of Toronto)
    Mechanisms that regulate the pressure-dependent activation of sphingosine kinase 1 in resistance artery smooth muscle cells
    2009, Renewal,  $80 916
  • Bonen, Arend (University of Guelph)
    Regulation of fatty acid transport in the heart
    2006, Renewal,  $99 022
  • Brooks, Dina (University of Toronto)
    Effect of cardiac rehabilitation for individuals after transient ischemic attack
    2009, New Annual (Pending), $80 000
  • Cameron, Jill I. (University of Toronto)
    Optimizing stroke family caregiver support across the care continuum by improving the timing of intervention delivery
    2009, New Annual (Pending), $104 661
  • Carrier, Marc (Ottawa Hospital Research Institute)
    Screening for previously undiagnosed malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using a comprehensive computed tomography of the abdomen/pelvis
    2009, New Annual (Pending), $80 000
  • Cattral, Mark S. (University Health Network)
    Role of immedate dendritic cell precursors in allograft rejection and tolerance
    2008, New Annual, $76 694
  • Chan, Anthony K.C. (McMaster University)
    Carbohydrate variation effects in the protein C pathway during development
    2008, New Annual, $79 564
  • Chan, Anthony K.C. (McMaster University)
    Surface mechanisms of anticoagulant ATH complex
    2007, Renewal  (Pending), $89 418
  • Chan, Christopher T.M. (University Health Network)
    Towards an improved understanding of vascular progenitor cell biology in uremia
    2009, New Annual (Pending), $65 703
  • Chen, Hsiao-Huei (Ottawa Hospital Research Institute)
    Mechanisms to reduce injury and improve recovery from stroke
    2008, New Annual, $106 511
  • Cherney, David Z.I. (University Health Network)
    Hemodynamic and molecular mechanisms of hyperfiltration in type I diabetes mellitus
    2009, New Annual, $78 795
  • Chidiac, Peter (University of Western Ontario)
    Impact of RGS proteins on cardiovascular function
    2008, Career Investigator, $87 950
  • Ciriello, John (University of Western Ontario)
    Leptin links obstuctive sleep apnea, obesity and hypertension
    2008, New Annual, $112 193
  • Connelly, Kim A. (St. Michael's Hospital)
    Role of TGFb acetylation in the pathogenesis of diabetic cardiomyopathy
    2009, Clinician Scientist, $64 000
  • Connelly, Philip W. (St. Michael's Hospital)
    Studies of the lactonase activity of paraoxonase 1 - an HDL associated enzyme of relevance to cardiovascular disease
    2008, Renewal,  $80 000
  • Copeland, John W. (University of Ottawa)
    Role of formin proteins in shear stress-induced cytoskeletal remodeling in endothelial cells
    2008, Renewal,  $108 585
  • Cote, Graham P. (Queen's University)
    Formation and function of invadopodia in vascular smooth muscle cells
    2007, Renewal (Pending), $94 105
  • Cregan, Sean P. (Robarts Research Institute)
    Mechanisms of P53 induced neuronal apoptosis
    2008, New Annual, $79 705
  • Crowther, Mark A. (McMaster University)
    Reducing cardiovascular disease by improving our use of antithrombotic agents.
    2009, Career Investigator, $87 950
  • Crowther, Mark A. (McMaster University)
    Does low dose oral vitamin K improve the quality of warfarin anticoagulation
    2009, New Annual (Pending), $129 852
  • Cybulsky, Myron I. (University Health Network)
    Initiation of atherosclerosis: mechanisms and cell biology
    2007, Career Investigator (Pending), $87 950
  • Cybulsky, Myron I. (University Health Network)
    Endothelial cell NF-kappaB homeostasis and function in atherosclerosis
    2009, New Annual, $124 266
  • Daneman, Denis (Hospital for Sick Children)
    Adolescent type 1 Diabetes cardio-renal Intervention trial (AdDIT)
    2009, New Annual, $91 205
  • Davis, Darryl R. (University of Ottawa Heart Institute)
    Mechanism of therapy: cardiac stem cells in myocardial repair
    2009, Clinician Scientist, $64 000
  • Dawson, John F. (University of Guelph)
    Expression and characterization of human cardiac actin mutants linked to hypertrophic and dilated cardiomyopathies
    2008, New Annual, $79 556
  • Demers, Catherine (McMaster University)
    The impact of mild cognitive deficits at hospital discharge on self-care in older heart failure patients
    2009, New Annual (Pending), $98 092
  • Dick, Alexander J. (Sunnybrook Health Sciences Centre)
    Endothelial progenitor cell modification to improve left ventricular function post myocardial infarction
    2008, Clinician Scientist, $70 250
  • Dick, Alexander J. (Sunnybrook Health Sciences Centre)
    Endothelial progenitor cell modification to improve left ventricular function post myocardial infarction
    2008, Renewal,  $78 008
  • Dorian, Paul (St. Michael's Hospital)
    Studies of the effect of fish oil derived omega-3 Polyunsaturated fatty acids ( EPA and DHA), and omega-6 fatty acids on experimental atrial fibrillation, and mechanisms of their antiarrhythmic effects
    2009, New Annual (Pending), $116 826
  • Dos Santos, Claudia C. (St. Michael's Hospital)
    The Role of PGC1a in sepsis-induced myocardial depression
    2008, Clinician Scientist, $64 000
  • Drangova, Maria (Robarts Research Institute)
    Cardiac imaging for therapy guidance and pre-clinical research studies
    2007, Career Investigator (Pending), $87 950
  • Drangova, Maria (Robarts Research Institute)
    Dynamic micro-CT for pre-clinical cardiac imaging
    2008, Renewal,  $118 204
  • Egan, Mary (University of Ottawa)
    Engaging in values activities post stroke
    2009, New Annual (Pending), $47 287
  • Eikelboom, John W.A. (McMaster University)
    Thrombotic mechanisms as predictors of Vascular events In non-cardiac Surgery patIents cohOrt evaluatioN (ThromboVISION)
    2009, New Annual (Pending), $130 301
  • Emili, Andrew (University of Toronto)
    Mechanistic investigation of microRNA-mediated regulation of dilated cardiomyopathy (DCM)
    2008, New Annual, $96 378
  • Fehlings, Michael G. (University Health Network)
    The ischemic axon: cross-talk with myelin in K+ channel terms
    2008, Renewal,  $84 389
  • Feldman, Ross D. (Robarts Research Institute)
    Determinants of adenylyl cyclase-mediated vascular responses.
    2009, Renewal,  $148 729
  • Feng, Qingping (London Health Sciences Centre)
    Cardioprotection by erythropoietin: role of nitric oxide
    2007, Renewal  (Pending), $127 060
  • Feng, Qingping (University of Western Ontario)
    Heart development in diabetes: role of nitric oxide
    2009, New Annual (Pending), $123 206
  • Ferguson, Alastair V. (Queen's University)
    Adiponectin actions in autonomic control centres of the brain
    2007, Renewal (Pending), $124 688
  • Ferguson, Stephen G. (Robarts Research Institute)
    Molecular regulation of G protein-coupled receptor signal transduction, desensitization and resensitization
    2008, Career Investigator, $87 950
  • Ferguson, Stephen G. (Robarts Research Institute)
    Regulation of G protein-coupled receptor signaling desensitization and resensitization
    2006, Renewal,  $126 523
  • Floras, John S. (University Health Network)
    Neural regulation of the circulation in human heart failure and hypertension
    2008, New Annual, $134 406
  • Floras, John S. (University Health Network)
    Central regulation of autonomic  cardiovascular function in human heart failure and sleep apnea
    2008, New Annual, $60 287
  • Fowler, Robert A. (Sunnybrook Health Sciences Centre)
    Prospective economic analysis in the prophylaxis for thrombolism in critical care trail
    2009, Clinician Scientist, $70 250
  • Fowler, Robert A. (Sunnybrook Health Sciences Centre)
    E-PROTECT: prospective economic analysis in the prophylaxis for thromboembolism in critical care trial
    2008, New Annual, $63 149
  • Funk, Colin D. (Queen's University)
    Lipoxygenase and cyclooxygenase pathways in cardiovascular disease
    2006, Career Investigator, $87 950
  • Gagnon, France (University of Toronto)
    Genome-wide search for oligogenes in factor V leiden thrombophilia
    2008, Renewal,  $111 886
     
  • Gaisano, Herbert Y. (University of Toronto)
    SNARE regulation of cardiac sulfonylurea receptor. A novel drug target for cardiac ischemia
    2007, Renewal  (Pending), $105 111
  • Giacca, Adria (University of Toronto)
    Vasculoprotective effect of insulin in vivo
    2008, Renewal,  $79 631
  • Giordano, Celine (University of Ottawa)
    Functional comparison of circulating progenitor cell subpopulations for cell-based angiogenesis
    2009, Master's Studentship (Pending),$18 500
  • Gladstone, David J. (Sunnybrook Health Sciences Centre)
    Improving the detection and treatment of atrial fibrillation following transient ischemic attack and stroke
    2009, Clinician Scientist, $70 250
  • Gollob, Michael H. (University of Ottawa Heart Institute)
    Insight into the mechanisms of atrial fibrillation
    2009, Clinician Scientist, $70 250
  • Grace, Sherry L. (University Health Network)
    An RCT of women's adherence to women-only, home-based and traditional cardiac rehabilitation (Cardiac Rehabilitation for Her heart Event Recovery [CR4HER])
    2009, New Annual, $108 179
  • Gramolini, Anthony O. (University of Toronto)
    Investigation of phospholamban mutations, sarcoplasmic reticulum calcium defects, and dilated cardiomyopathy
    2008, Renewal, $98 597
  • Grant, David R. (University Health Network)
    fgl2/FGL2 and xenograft transplantation
    2008, Renewal,  $88 600
  • Gross, Peter L. (McMaster University)
    Defining how atorvastatin inhibits platelets
    2009, Renewal,  $80 000
  • Grover, Ashok K. (McMaster University)
    Caloxins: novel inhibitors of plasma membrane calcium pumps
    2008, Renewal,  $79 256
  • Gula, Lorne J. (University of Western Ontario)
    Monitoring of Ventricular Rhythm & Exercise - ICD study (MOVE-IT)
    2009, New Annual (Pending), $72 468
  • Hammond, James R. (University of Western Ontario)
    Role of nucleoside/nucleobase transporters in the regulation of the vascular effects of adenosine and its metabolites
    2008, Renewal,  $78 637
  • Hayward, Catherine P. (McMaster University)
    Functions of multimerin 1 as a platelet adhesive protein
    2009, Renewal,  $80 000
  • Heckman, George A.W. (McMaster University)
    Adapting the Canadian Cardiovascular Society recommendations on heart failure: a consensus-based approach with stakeholder input
    2009, New Annual (Pending), $79 788
  • Hegele, Robert A. (Robarts Research Institute)
    Phenomics and genomics of atherosclerosis in monogenic metabolic syndrome
    2007, Renewal  (Pending), $112 436
  • Hegele, Robert A. (Robarts Research Institute)
    Genomics of hypertriglyceridemia
    2009, Renewal,  $164 036
  • Heximer, Scott P. (University of Toronto)
    Defining the molecular pathways through which RGS4 regulates parasympathetic signaling and heart rate control in sinoatrial node myocytes
    2009, Renewal,  $149 220
  • Hinek, Aleksander (Hospital for Sick Children)
    Elastin and elastin receptor as crucial factors modulation cellular funtions in cardiovascular development and diseases
    2008, Renewal,  $122 645
  • Holden, Rachel M. (Queen's University)
    Mechanisms of vascular calcification (VC) in a model of chronic kidney disease (CKD)
    2009, New Annual (Pending), $88 011
  • Holdsworth, David W. (Robarts Research Institute)
    Investigation of flow in the stenosed carotid bifurcation
    2008, Renewal,  $114 838
  • Hou, Sheng T. (University of Ottawa)
    Investigation of SEMA3A's role in angiogenesis and vascular permeability during stroke recovery
    2009, Renewal,  $72 575
     
  • Hough, Margaret R. (Sunnybrook Health Sciences Centre)
    Cardiac repair and regeneration
    2009, Renewal,  $80 000
  • Huff, Murray W. (Robarts Research Institute)
    Cellular Programs and Responses in Atherosclerosis
    2006, Program (Pending), $250 000
  • Husain, Mansoor (University Health Network)
    Plasma membrane Ca2+ ATPase 4 isoforms: regulation and role in cardiac and smooth muscle
    2009, New Annual (Pending), $118 118
  • Husain, Mansoor (University Health Network)
    The role of glucagon-like peptide-1 in cardiac health and disease
    2009, Renewal, $142 380
  • Husain, Mansoor (University of Toronto)
    Molecular studies of cardiac and vascular disease.
    2009, Career Investigator, $87 950
  • Ikura, Mitsuhiko (University Health Network)
    Structural elucidation of intracellular calcium transporters
    2006, Renewal,  $105 258
  • Karkouti, Keyvan (University Health Network)
    Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: a proof of concept pilot study.
    2009, New Annual (Pending), $36 001
  • Kearon, Clive (McMaster University)
    Optimizing treatment and diagnosis of venous thromboembolism
    2008, Career Investigator, $87 950
  • Keeley, Fred W. (Hospital for Sick Children)
    Recombinantly expressed elastin-like polypeptides as a novel tool for investigations of the structure, assembly, and the properties of elastin-like materials
    2009, Renewal,  $131 821
  • Keith, Mary E. (St. Michael's Hospital)
    A randomized controlled trial of the effect of thiamin supplementation on heart function in ambulatory patients with heart failure
    2009, New Annual (Pending), $126 849
  • Kelley, Beverley (University of Ottawa)
    Navigating Community Care Post-Stroke: An Examination of Older Adults' Experiences
    2009, Fellowship, $31 000
     
  • Khokha, Rama (University Health Network)
    Molecular dissection of the distinct functions of TIMP-3 and TIMP-4 in heart disease
    2009, Renewal, $114 381
  • Kislinger, Thomas (University Health Network)
    Identification and characterization of cell-surface associated protein in the heart: applications of a novel proteomic strategy
    2009, New Annual, $129 261
  • Koschinsky, Marlys L. (Queen's University)
    The pathophysiology of Lp(a) in the arterial wall: effect of Apo(a) on vascular cell function
    2006, Renewal,  $104 368
  • Koschinsky, Marlys L. (University of Windsor)
    Mechanisms of atherothrombosis: analysis of lipoprotein and fibrinolytic risk factors
    2006, Career Investigator, $87 950
  • Koschinsky, Marlys L. (University of Windsor)
    Modulation of the TAFI pathway in health and disease: mechanistic analysis of the regulation of TAFI gene expression in hepatic and extrahepatic cells
    2008, New Annual, $120 558
  • Krahn, Andrew D. (University of Western Ontario)
    Inherited arrhythmias: clinical and genetic assessment of primary electrical disease
    2008, Career Investigator, $87 950
  • Krahn, Andrew D. (University of Western Ontario)
    Inherited causes of sudden death: phenotype genotype correlation
    2009, Renewal,  $170 089
  • Lagace, Thomas A. (University of Ottawa Heart Institute)
    Regulation of the PCSK9 binding interaction with LDL receptor
    2009, New Annual (Pending), $78 331
  • Lanctot, Krista L. (Sunnybrook Health Sciences Centre)
    The role of cytokine-serotonin interactions in post-stroke depression and cognitive symptoms
    2008, Renewal,  $94 587
  • Law, Sai Fai Bosco (McMaster University)
    Improving effectiveness of cardiac resuscitation through high fidelity simulation and team training
    2009, Master’s Studentship (Pending), $18 500
  • Lee, Jonathan M. (University of Ottawa)
    The role of elongation factor eEF1A2 in obesity
    2008, New Annual, $71 921
  • Lee, Ting-Yim (Lawson Health Research Institute)
    Prediction of hemorrhagic transformation of ischemic stroke with CT perfusion derived blood-brain-barrier permeability surface area product
    2009, New Annual, $90 096
  • Leenen, Frans H.H. (University of Ottawa Heart Institute)
    RAS blockade and sympathetic activity in humans post MI
    2008, New Annual, $110 881
  • Leong-Poi, Howard M. (St. Michael's Hospital)
    Ultrasound-targeted gene and cell-based strategies for therapeutic angiogenesis
    2008, Clinician Scientist, $70 250
  • Leong-Poi, Howard M. (St. Michael's Hospital)
    Role of statins in progenitor cell therapy for chronic ischemia
    2009, New Annual (Pending), $74 868
  • Lewis, Gary F. (University Health Network)
    The role of C-reactive protein (CRP) in modulating insulin action and insulin secretion
    2008, New Annual, $85 948
  • Lewis, Gary F. (University of Toronto)
    Determining the mechanisms of the dyslipidemia of insulin resistant states and Type 2 diabetes
    2008, Career Investigator, $43 975
  • Leytin, Valery (St. Michael's Hospital)
    Mitochondrial control of platelet apoptosis
    2008, Renewal,  $99 489
     
  • Li, Ren-Ke (University Health Network)
    Restoration of cardiac function: cellular regeneration and matrix reconstruction
    2006, Career Investigator, $87 950
  • Li, Ren-Ke (University Health Network)
    Modifying cardiac repair using molecular and cellular interventions
    2009, Renewal,  $80 000
  • Liaw, Patricia C.Y. (McMaster University)
    Studies of the endothelial cell protein C receptor (EPCR)
    2008, New Annual, $121 160
  • Licht, Christoph P.B. (Hospital for Sick Children)
    Atypical hemolytic uremic syndrome: a new pathological role for complement and coagulation control in platelets
    2009, New Annual (Pending), $96 878
  • Lillicrap, David (Queen's University)
    Gain-of-function mutants affecting the glycoprotein Ib/von Willebrand factor interaction: Potential novel antithrombotic molecules
    2008, New Annual, $142 860
  • Linkins, Lori-Ann (McMaster University)
    Evaluation of a diagnostic strategy for patients with suspected heparin-induced thrombocytopenia (HIT)
    2009, Renewal,  $39 907
  • Liu, Fang (Centre for Addiction and Mental Health)
    Functional and molecular characterization of protein-protein interaction between AMPA receptors and GAPDH (Glyceraldehyde-3-phosphate Dehydrogenase)
    2008, Renewal,  $95 300
  • Liu, Peter P. (University Health Network)
    Strategies to optimize mobilization, homing and reconstitution therapy in cardiac repair post-infarction
    2009, Renewal, $80 000
  • Mak, Alan S. (Queen's University)
    Cortactin and caldesmon in vascular smooth muscle cell migration and invasion
    2006, Renewal,  $100 559
  • Mak, Susanna (Mount Sinai Hospital)
    Studies of sympathetic nervous system activation in patients with pulmonary arterial hypertension
    2008, New Annual, $57 596
  • Mak, Susanna (Mount Sinai Hospital)
    Sex determinants of left ventricular mechanical performance in humans with and without heart failure
    2008, New Annual, $63 814
  • Marcel, Yves L. (University of Ottawa Heart Institute)
    Low HDL syndrome and the inflamed monocytes
    2009, Renewal,  $80 000
  • Mark, Amy E. (University of Ottawa Heart Institute)
    Intervention for dietary behaviour change among individuals at risk for CHD
    2009, Fellowship, $59 500
  • Marsden, Philip A. (University of Toronto)
    The human nitric oxide synthase genes: relevance to disease
    2008, Career Investigator, $43 975
     
  • Marsden, Philip A. (University of Toronto)
    Regulated expression of the human nNOS gene
    2006, Renewal,  $115 303
  • Marsden, Philip A. (University of Toronto)
    Post-transcriptional regulation of endothelial gene expression
    2009, Renewal,  $129 915
  • Martino, Tami A. (University of Guelph)
    Circadian control of cardiac remodeling
    2008, New Annual (Pending), $78 981
  • Maurice, Donald H. (Queen's University)
    PDEs in blood vessels
    2006, Career Investigator, $87 950
  • Maurice, Donald H. (Queen's University)
    Phosphodiesterases in arteries
    2008, Renewal, $96 592
  • McBride, Heidi M. (University of Ottawa Heart Institute)
    Mechanism and function of mitochondrial derived vesicles
    2008, Renewal,  $125 415
  • McCrindle, Brian W. (Hospital for Sick Children)
    Increasing physical activity among children with congenital heart defects
    2009, Renewal,  $208 062
  • McCulloch, Christopher A.G. (University of Toronto)
    Role of intercellular adhesions in diabetic cardiomyopathy
    2009, New Annual (Pending), $95 620
  • McPherson, Mark A. (Queen's University)
    Physical activity as a determinant of melatonin levels in rotating shift nurses
    2009, Master’s Studentship (Pending), $18 500
  • McPherson, Ruth (University of Ottawa Heart Institute)
    Genotype to phenotype: functional analysis of CHD genetic variants
    2009, New Annual (Pending), $78 827
  • Mecredy, Graham C. (Queen's University)
    Built environments as determinants of cardioprotective behaviours in Canadian adolescents
    2009, Master’s Studentship (Pending), $18 500
  • Mehta, Sanjay (London Health Sciences Centre)
    Complex regulation of microvascular endothelial cell function in sepsis
    2008, Renewal,  $121 364
  • Min, Wei-Ping (University of Western Ontario)
    Preventing heart graft rejection by inhibiting innate and adaptive alloimmunity through gene silencing of toll-like receptors
    2009, Renewal,  $79 640
  • Morshead, Cindi M. (Out of Ontario)
    The development of drug and cell delivery systems for use in cell based therapies to treat stroke
    2008, New Annual, $40 000
  • Morshead, Cindi M. (University of Toronto)
    The development of drug and cell delivery systems for use in cell based therapies to treat stroke
    2008, New Annual, $144 650
  • Murkin, John M. (London Health Sciences Centre)
    Genetic determinants of neurocognitive dysfunction following cardiopulmonary bypass
    2008, Renewal, $87 078
  • Nanthakumar, Kumaraswamy (University Health Network)
    Electrophysiological implications of regenerative therapy
    2009, New Annual (Pending), $90 985
  • Nemer, Mona (University of Ottawa)
    Mechanisms of TBX5 action in the heart
    2008, New Annual, $118 196
  • Ng, Dominic S.K. (St. Michael's Hospital)
    Regulation of lipids, insulin action and cell stress in LCAT deficient mice
    2008, New Annual, $119 932
  • Ni, Heyu (St. Michael's Hospital)
    Novel mechanisms of platelet aggregation: unveiling new roles of non-classical beta3 integrin ligands in thrombosis and hemostasis
    2008, Renewal, $115 494
  • Nurse, Colin A. (McMaster University)
    Functional and anatomical characterization of rat aortic body chemoreceptors
    2009, New Annual (Pending), $77 106
  • O'Brien, Edward R.M. (University of Ottawa Heart Institute)
    Extracellular and intracellular vascular roles of HSP27:  an estrogen receptor beta associated heat shock protein
    2008, Renewal, $79 936
  • Opas, Michal J. (University of Toronto)
    The role of calreticulin in cardiac remodelling
    2009, New Annual (Pending), $68 905
  • Park, David S. (University of Ottawa)
    Pathways which regulate neuronal death
    2006, Career Investigator, $87 950
  • Park, David S. (University of Ottawa)
    Oxidative stress and ischemic death
    2008, Renewal,  $123 066
  • Park, David S. (University of Ottawa)
    Mechanism of delayed death in stroke
    2009, Renewal,  $136 414
  • Parker, John D. (Mount Sinai Hospital)
    Development of a new technique to assess endothelial function: flow mediated constriction
    2008, New Annual, $133 653
  • Parker, John D. (University of Toronto)
    Clinical studies concerning nitrate pharmacology and autonomic physiology in congestive heart failure
    2007, Career Investigator (Pending), $87 950
  • Parker, John D. (University of Toronto)
    The Sifton Distinguished Scientist Award
    2008, Sifton Award, $10 000
  • Parker, Thomas G. (St. Michael's Hospital)
    EF-hand proteins, S100A1 and A6, in cardiovascular pathophysiology
    2008, New Annual, $121 241
  • Parkinson, John (Hospital for Sick Children)
    An interdisciplinary approach to identifying and characterizing polymorphisms in tropoelastin and their role in late onset cardiovascular disease
    2009, Renewal,  $113 392
  • Peng, Tianqing (London Health Sciences Centre)
    Role of calpain activation in myocardial dysfunction in sepsis
    2008, New Annual, $106 117
  • Peng, Tianqing (London Health Sciences Centre)
    Targeting mitochondrial redox signaling to prevent myocardial dysfunction in sepsis
    2009, Renewal,  $110 576
  • Pickering, J. Geoffrey (University of Western Ontario)
    Role of smooth muscle cells in vascular disease
    2008, Career Investigator, $43 975
  • Pilote, Louise (McGill University)
    Genesis praxy: Gender and sex determinants of cardiovascular disease from bench to beyond in premature acute coronary syndrome
    2008, New Annual, $45 524
  • Pilote, Louise (Out of Ontario)
    Genesis praxy: Gender and sex determinants of cardiovascular disease from bench to beyond in premature acute coronary syndrome
    2008, New Annual, $140 831
  • Prado, Marco A.M. (Robarts Research Institute)
    Decreased cholinergic tone and heart dysfunction
    2009, New Annual, $126 288
  • Rac, Valeria E. (St. Michael's Hospital)
    Prehospital Evaluation and Economic Analysis f Different Coronary Syndrome Treatment Strategies - PREDICT
    2009, Fellowship, $59 500
  • Rao, Vivek (University Health Network)
    EGFL-7, rapamycin and transplant vasculopathy
    2009, Renewal, $61 530
  • Redington, Andrew N. (Hospital for Sick Children)
    The effect of remote ischemic preconditioning on clinical and genomic responses to open heart surgery in children
    2009, New Annual (Pending), $167 565
     
  • Reid, Robert D. (University of Ottawa Heart Institute)
    Efficacy and cost-effectiveness of cost-free pharmacotherapy for smoking cessation for high-risk smokers with cerebrovascular disease
    2009, New Annual (Pending), $223 389
  • Retnakaran, Ravi R. (Mount Sinai Hospital)
    The early natural history of cardiovascular disease at 4-years postpartum in young women with varying degrees of glucose intolerance in pregnancy
    2009, New Annual (Pending), $60 294
  • Rocca, Antonio (University of Toronto)
    Mediation of Flow-Induced Arterial Remodelling
    2008, Clinician Scientist, $64 000
  • Rocheleau, Jonathan V. (University Health Network)
    Interaction between vascular endothelial cells and pancreatic beta cells: understanding the role of fibroblast growth factor (FGF)
    2009, New Annual (Pending), $87 084
  • Rodger, Marc A. (Ottawa Hospital Research Institute)
    Thrombophilia and placenta mediated pregnancy complications
    2007, Career Investigator (Pending), $87 950
  • Rodger, Marc A. (Ottawa Hospital Research Institute)
    Recurrent venous thromboembolism risk stratification evaluation (REVERSE) : long term follow-up to define if lifelong anticoagulation is required in high risk patients with a first unprovoked venous thromboembolism
    2009, New Annual, $110 269
  • Rose, David R. (University Health Network)
    The molecular basis for starch digestion in the intestine: Human maltase-glucoamylase and sucrase-isomaltase
    2008, New Annual, $82 604
  • Roy, Eric A. (University of Waterloo)
    Neuropsychological profiles and neuroanatomic correlates of limb apraxia
    2007, Renewal  (Pending), $69 864
  • Ruel, Marc Andre (University of Ottawa Heart Institute)
    Evaluation of biopolymer delivered EPCs for cardiac repair in a swine model of hibernating myocardium
    2009, Renewal, $795 36  NUMBER MISSING???
  • Rui, Tao (London Health Sciences Centre)
    Role of HMGB1 in ischemia/reperfusion-induced myocardial injury
    2008, New Annual, $97 895
  • Salbach, Nancy M. (University of Toronto)
    Building physiotherapists' capacity to implement evidence-based stroke rehabilitation
    2008, Clinician Scientist, $64 000
  • Saposnik, Gustavo (St. Michael's Hospital)
    Premature Stroke Associated with Recency of Immigration to Ontario (PRESARIO)
    2008, Clinician Scientist, $64 000
  • Schlichter, Lyanne C. (University Health Network)
    Pathophysiology and inflammation after intracerebral hemorrhage
    2008, Renewal, $110 497
  • Schlichter, Lyanne C. (University Health Network)
    Modulating modes of microglial activation to reduce secondary stroke injury
    2009, Renewal,  $116 223
  • Shah, Baiju R. (Sunnybrook Health Sciences Centre)
    Diabetes care and outcomes for people with Chinese and South Asian origins
    2008, New Annual, $30 657
     
  • Shaughnessy, Stephen G. (McMaster University)
    Mechanism(s) of low molecular weight heparin-induced bone loss
    2009, New Annual (Pending), $80 000
  • Sheffield, William P. (McMaster University)
    Exploring engineered serpins as potential antithrombotic agents
    2008, Renewal, $98 750
  • Sheffield, William P. (McMaster University)
    Transforming hirudin into an activatable, clot-localized thrombin inhibitor
    2009, Renewal, $98 232
  • Shoemaker, J. Kevin (University of Western Ontario)
    Plasticity of cortical-cardiovascular interactions in vascular disease
    2008, Renewal, $79 756
  • Simmons, Craig A. (University of Toronto)
    The role of C-type natriuretic peptide in cardiac valve fibrosis
    2009, New Annual (Pending), $89 473
  • Slack, Ruth (Ottawa Hospital Research Institute)
    Regulation of Mcl1 to treat stroke
    2006, Renewal,  $104 254
  • So, Derek Y.F. (University of Ottawa Heart Institute)
    Obstructive sleep apnea as a risk factor for clopidogrel unresponsiveness in patients undergoing percutaneous coronary intervention: prevalence, mechanisms and possible influence on clinical outcomes
    2009, New Annual, $79 100
  • Sofrenovic, Tanja (University of Ottawa)
    Enhanced matrix for recruitment of circulating progenitor cells to the heart
    2009, Master’s Studentship (Pending), $18 500
  • Sorisky, Alexander (Ottawa Hospital Research Institute)
    MAPping adipose tissue malfunction in obesity: macrophages, adipose cells, and PDGF
    2009, New Annual, $138 633
  • Spafford, J. David (University of Waterloo)
    Structure-function analyses of drug interactions with L-type calcium channels
    2008, New Annual, $78 882
  • Sparks, Daniel L. (University of Ottawa Heart Institute)
    The role of HDL in triglyceride metabolism
    2008, Renewal,  $80 000
  • Spencer, Frederick A. (McMaster University)
    Clinical epidemiology and management of cardiovascular and venous thromboembolic disease
    2007, Career Investigator (Pending), $87 950
  • Spencer, Frederick A. (McMaster University)
    Fortinos Distinguished Scientist Award
    2007, Fortinos Award, $10 000
  • St. Lawrence, Keith S. (London Health Sciences Centre)
    Oxygen consumption is an early predictor of brain damage following hypoxia-ischemia
    2009, New Annual (Pending), $88 730
  • Stagljar, Igor (University of Toronto)
    Functional analysis of the interactome of the human B-adrenergic receptors
    2009, New Annual (Pending), $92 563
  • Steinman, David A. (University of Toronto)
    Hemodynamic factors in vascular disease: from bench to bedside
    2009, Career Investigator, $87 950
  • Steinman, David A. ( University of Toronto)
    Flow in the common carotid artery is not fully-developed: implications for studies of atherosclerosis
    2009, New Annual (Pending), $47 023
  • Sugita, Shuzo (University Health Network)
    The roles of CAPS1 in catecholamine secretion
    2009, Renewal,  $78 387
  • Suskin, Neville G. (Lawson Health Research Institute)
    Comprehensive cardiac rehabilitation programming for patients following transient ischemic attack (extension)
    2009, Renewal,  $157 404
  • Suuronen, Erik J. (University of Ottawa Heart Institute)
    Recruitment of endogenous circulating progenitor cells for cardiac regeneration using enhanced tissue-engineered biomatrices
    2009, Renewal,  $130 078
     
  • Syme, Catriona A. (Hospital for Sick Children)
    Determinants of Cardiovascular and Metabolic Risk in Overweight Children and Adolescents
    2009, Fellowship, $59 500
  • Syrett, Andrew J. (University of Ottawa)
    Bioactive glycerophospholipids and their role in modulating neuronal vulnerability following ischemia
    2009, Master’s Studentship (Pending), $18 500
  • Tang, Damu (McMaster University)
    Characterization of a novel insig binding protein (INsigBP1)
    2008, New Annual, $81 500
  • Tesson, Frederique (University of Ottawa)
    Cell nucleus and dilated cardiomyopathy
    2009, New Annual (Pending), $96 389
  • Tobe, Sheldon W. (Sunnybrook Health Sciences Centre)
    Harmony study (Hypertension analysis of stress reduction using mindfulness meditation and yoga)
    2008, New Annual, $75 197
  • Touyz, Rhian M. (Ottawa Hospital Research Institute)
    TRPM7 signaling through lipid rafts in vascular smooth muscle cells - implications in hypertension
    2008, Renewal,  $11 7395 (WHAT IS CORRECT AMMOUNT??)
  • Tsushima, Robert G. (York University)
    SNARE protein regulation of cardiac ion channels and ANF secretion.
    2009, Career Investigator, $87 950
  • Tsushima, Robert G. (York University)
    Cell signalling in myocardial ischemia preconditioning
    2008, New Annual, $79 700
  • Tsushima, Robert G. (York University)
    SNARE protein regulation of cardiac ion channels and ANF secretion
    2009, Renewal, $101 500
  • Tulloch, Heather E. (University of Ottawa Heart Institute)
    Interventions to reduce cardiovascular disease: ""real world"" effectiveness of combined pharmacotherapy and behavioral counselling for smoking cessation
    2009, New Annual (Pending), $253 366
  • Van Huysse, James W. (University of Ottawa Heart Institute)
    Roles of the brain Na, K-ATPase alpha isoforms in the regulation of blood pressure
    2008, New Annual, $76 018
  • Veerman, Kaley J. (McMaster University)
    Investigating the role of the vasa vasorum in the development of diabetic atherosclerosis
    2009, Master’s Studentship (Pending), $18 500
  • Verma, Subodh (St. Michael's Hospital)
    Elucidating the in vivo role of adiponectin in inflammation: a biochemical and pharmacological approach
    2009, New Annual (Pending), $65 979
  • Verma, Subodh (St. Michael's Hospital)
    Neuregulin-1 as a novel treatment for endothelial dysfunction and atherosclerosis
    2009, New Annual (Pending), $80 000
  • von Harsdorf, Rudiger (University Health Network)
    Evaluation of p21CIP1/WAF1 protein transduction as a novel therapeutic approach in heart failure
    2008, New Annual, $80 000
  • Wade, Terrance J. (Brock University)
    Social Determinants of Child Hypertension
    2007, Social Determinants, $100 010
     
  • Walley, Keith R. (Out of Ontario)
    Genetic determinants of neurocognitive dysfunction following cardiopulmonary bypass
    2008, Renewal,  $80 000
  • Wang, Hao (University of Western Ontario)
    Soluble CD83 based therapy in cardiac allograft tolerance
    2008, Renewal, $79 967
  • Ween, Jon Erik (Baycrest)
    Refinement of a point-of-care, electronic testing tool for the longitudinal stroke assessments
    2009, New Annual (Pending), $80 000
  • Weitz, Jeffrey I. (McMaster University)
    Impact of gamma' fibrinogen on clot formation and clot lysis at sites of plaque rupture
    2008, Renewal,  $118 563
  • Wells, James W. (University of Toronto)
    Nature of the signalling complex between cardiac muscarinic receptors and G proteins
    2008, Renewal,  $85 052
     
  • Wells, Philip S. (Ottawa Hospital Research Institute)
    Development and validation of clinical prediction rules for bleeding for patients on anticoagulant therapy for venous thromboembolism
    2008, New Annual, $191 647
  • Wen, Xiao-Yan (St. Michael's Hospital)
    Roles of novel lpdl and lpdlr phospholipases in platelet activation and thrombosis
    2009, Renewal,  $118 125
  • White, James A. (London Health Sciences Centre)
    Multi-modality imaging assessment for pacing interventions in heart failure (MAPIT-HF)
    2008, New Annual, $116 610
  • White, James A. (University of Western Ontario)
    Myocardial Scar Imaging in Heart Failure: Prediction of Risk and Therapeutic Response
    2009, Clinician Scientist, $64 000
  • Whitman, Stewart C. (University of Ottawa Heart Institute)
    The role of the innate immune system in atherosclerosis: Further defining the role of NKT cells, interferon-gamma and IL-4 in the disease process
    2008, Renewal,  $108 184
  • Yang, Burton B. (Sunnybrook Health Sciences Centre)
    Roles of versican in mediating leukocyte and endothelial cell activities
    2006, Career Investigator, $87 950
  • Yang, Burton B. (Sunnybrook Health Sciences Centre)
    Roles of miR-17-5p in endothelial wound healing and angiogenesis
    2008, New Annual, $82 060
  • Yang, Burton B. (Sunnybrook Health Sciences Centre)
    MicroRNA miR-378 regulates self renewal and angiogenesis
    2009, New Annual (Pending), $103 720
  • Yeung, Rae S.M. (Hospital for Sick Children)
    Towards a better understanding of kawasaki disease
    2008, Renewal,  $79 870
  • Zandstra, Peter W. (University of Toronto)
    Interrogating the cardiomyogenic hierarchy to optimize cardiovascular cell therapy
    2009, Renewal,  $143 700
  • Zhang, Shetuan (Queen's University)
    Control of cell surface channel density by potassium as a novel mechanism for hERG regulation
    2009, Renewal,  $142 295
  • Zhang, Wandong (University of Ottawa)
    Modulation of MMP9 expression induced by cerebral ischemia and reperfusion to reduce blood-brain barrier permeability and brain damage in ischemic stroke
    2008, New Annual, $56 200
  • Zhang, Zhu-Xu (London Health Sciences Centre)
    Therapeutic potential and mechanism of double-negative regulatory T (DN-Treg) cells mediated tolerance in heart transplantation
    2009, Renewal,  $92 080

     

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