Confirmation of Budget Commitment for the 2nd Year of Funding - Results of Competition 1999

For grants that were awarded in the September 1999 competition, the Heart and Stroke Foundation of Ontario is pleased to announce confirmation of the 2nd year budget commitment on multi-year Grants-in-Aid and Personnel Awards. These grants took effect July 1, 2000. An official letter will also be sent to all applicants shortly. For those awards identified as “pending”, funding is encumbered until additional information is provided. With regard to projects that have been identified as being “applied” or “clinically oriented”, in keeping with the Foundation’s Progress Report policy, funding is encumbered pending the May 15, 2001 Progress Report.

September 2000 Competition Funding Decisions

The funding decisions for the September 2000 competition will be announced by the end of February on the national website www.hsf.ca/research.
  • Adeli, Khosrow (Hospital for Sick Children)
    Mechanisms and Regulation of Apolipoprotein B Degradation
    2nd Year Award, Renewal, $102,041
     
  • Alhesayen, Abdurrahman, O (Mount Sinai Hospital)
    Endothelin Kinetics in Human Congestive Heart Failure
    2nd Year Award, Fellowship, $51,600
     
  • Andrew, Maureen (Hamilton Civic Hospitals Research Centre)
    Fibrinolytic mechanisms and treatment of TE in the young
    2nd Year Award, Renewal, $64,780
     
  • Andrew, Maureen (The Hospital for Sick Children)
    Fibrinolytic mechanisms and treatment of thromboembolic disease in the young
    2nd Year Award, Career Investigator, $76,250
     
  • Arnold, J. Malcolm (London Health Sciences Centre)
    Vascular Responses in Heart Failure
    2nd Year Award, Renewal, $99,066
     
  • Arthur, Heather M. (McMaster University)
    Reducing Anxiety in Patients Awaiting Elective Cardiac Catheterization
    2nd Year Award, New Annual (Pending), $39,141
     
  • Baker, Robert Roy (University of Toronto)
    The Metabolism of Platelet activating factor in brain
    2nd Year Award, Renewal, $65,594
     
  • Bennett, Brian M. (Queen's University)
    Mechanisms of action and tolerance development to organic nitrates
    2nd Year Award, Renewal, $63,131
     
  • Bonen, Arend (University of Waterloo)
    Regulation of FAT/CD36 and fatty acid transport in the heart
    2nd Year Award, Renewal, $64,980
     
  • Brown, Arthur (The John P. Robarts Research Institute)
    Endocardial Cushion Defects in DphA3 Mutant Mice
    2nd Year Award, New Annual, $73,849
     
  • Bulman, Dennis E. (Ottawa Hospital Research Institute)
    Genetic Linkage Analysis in Congenital Bicuspid Aortic Valve
    2nd Year Award, New Annual, $68,050
     
  • Capone, John P. (McMaster University)
    Function and mechanisms of action of peroxisome proliferator-activated receptors
    2nd Year Award, Renewal, $132,239
     
  • Chretien, Michel (Loeb Research Institute)
    Proprotein Convertases: Implication for Management of Restenosis
    2nd Year Award, New Annual, $72,941
     
  • Cole, David E.C. (University of Toronto)
    Homocysteine and Cardiac Transplantation
    2nd Year Award, Renewal, $65,701
     
  • Coles, John G. (Hospital for Sick Children)
    Xenogenic Cardiomyocyte Transplantation
    2nd Year Award, New Annual, $65,244
     
  • Courtman, David W. (St. Michael's Hospital)
    Arterial Anastomotic Remodeling
    2nd Year Award, New Annual, $66,639
     
  • Cox, Peter (Hospital for Sick Children)
    Heparin Bonded Catheters and Thrombosis in Pediatric Critical Care Patients
    2nd Year Award, New Annual (Pending), $25,891
     
  • Cybulsky, Myron I. (Toronto General Hospital Research Inst)
    Regional activation of NF-kB signal transduction in arterial endothelium: role in atherogenesis
    2nd Year Award, New Annual, $91,290
     
  • D'Souza, Sudhir (London Health Sciences Centre)
    Dopamine receptors in renal tubule epithelial cells
    2nd Year Award, New Annual, $61,085
     
  • Durkin, Jon P. (National Research Council of Canada)
    Mechanism of MK-801 Pre-conditioning and Neuroprotection
    2nd Year Award, Renewal, $56,825
     
  • Ellis, Christopher (University of Western Ontario)
    Regulation of Microvascular Oxygen
    2nd Year Award, Renewal, $59,917
     
  • Feldman, Ross D. (The John P. Robarts Research Institute)
    Tyrosine kinase-mediated sensitization of adenylyl cyclase activation
    2nd Year Award, Renewal, $64,235
     
  • Ferguson, Alastair (Queen's University)
    Intrinsic conductances and protection from excitotoxic cell death
    2nd Year Award, Renewal, $61,341
     
  • Fliss, Henry (University of Ottawa)
    Myocardial reperfusion injury: the role of apoptosis
    2nd Year Award, Renewal, $66,725
     
  • Ginsberg, Jeffrey S. (McMaster University Medical Centre)
    Management of the Post Phlebitic Syndrome
    2nd Year Award, New Annual (Pending), $126,270
     
  • Graham, Charles H. (Queen's University)
    Oxygen-regulated gene expression in preeclamptic hypertension
    2nd Year Award, Renewal, $83,490
     
  • Grant, David (Toronto General Hospital)
    Prevention of Delayed Cardiac Xenograft Rejection by Modulation of the Potent FGL2 Prothbrombinase Gene
    2nd Year Award, New Annual, $67,711
     
  • Gros, Robert (Toronto General Hospital)
    Regulated expression of PMCA isoforms in arterial smooth muscle cells of transgenic mice
    2nd Year Award, Fellowship, $38,950
     
  • Guha, Abhijit (Toronto Western Hospital)
    Neoangiogenesis in Cerebral Ischemia
    2nd Year Award, Renewal, $93,300
     
  • Hakim, Antoine M. (University of Ottawa)
    Role of XIAP in calcium ion homeostasis
    2nd Year Award, New Annual, $62,000
     
  • Haslam, Richard J. (McMaster University)
    Mechanisms of cyclic nucleotide action
    2nd Year Award, Renewal, $67,602
     
  • Hayward, Catherine P. (McMaster University)
    Characterization of Multimerin as a Novel, Platelet and Vascular Adhesive Protein
    2nd Year Award, Renewal, $78,193
     
  • Hayward, Catherine P. (McMaster University)
    Serine Proteases in Normal and Pathologic Platelets
    2nd Year Award, New Annual, $80,863
     
  • Hayward, Catherine P. (McMaster University)
    Investigations of Novel Secretory Proteins in Platelets and Vascular Endothelium
    2nd Year Award, Career Investigator, $76,250
     
  • Hegele, Robert A. (Robarts Research Institute)
    Genetic determinants of coronary heart disease
    2nd Year Award, Career Investigator, $76,250
     
  • Hinek, Aleksander (Hospital for Sick Children)
    Role of Elastin receptor in Pathobiology of Arterial Thickening
    2nd Year Award, New Annual, $74,094
     
  • Holdsworth, David W. (J. P. Robarts Research Institute)
    Investigation of flow in the stenosed carotid bifurcation
    2nd Year Award, Renewal, $55,301
     
  • Hornberger, Lisa (The Hospital for Sick Children)
    B1 Integrins and the IFG2-IGF1 Receptor system in Fetal Cardiac Myocyte Proliferation: Regulatory Role for the Nuclear Transcription Factor, Sp1
    2nd Year Award, New Annual, $58,985
     
  • Hu, Bin (Loeb Health Research Institute)
    Cellular Mechanism Underlying Mannitol-Based Neuroprotection
    2nd Year Award, Renewal, $65,977
     
  • Huff, Murray W. (John P. Robarts Research Institute)
    Regulation of Apolipoprotein B Metabolism
    2nd Year Award, Renewal, $114,392
     
  • Hughson, Richard L. (University of Waterloo)
    Integrative Cerebrovascular and Cardiovascular Responses: Effects of Age and Gender
    2nd Year Award, New Annual, $36,549
     
  • Husain, Mansoor (The Toronto General Hospital)
    Conditional over-expression of PMCA sioforms in arterial SMC of transgenic mice
    2nd Year Award, New Annual, $65,433
     
  • Irvine, Jane (The Toronto Hospital)
    Home Exercise Training for Patients with Intermittent Claudication
    2nd Year Award, New Annual (Pending), $137,550
     
  • Karmazyn, Morris (University of Western Ontario)
    Endothelin/nitric oxide interaction in the regulation of cardiac function in health and disease 
    2nd Year Award, Renewal, $82,218
     
  • Katzmarzyk, Peter T. (York University)
    Genetics of Blood Pressure and Body Fatness in Canada: Cross-Trait and Longitudinal Analyses
    2nd Year Award, New Annual, $23,000
     
  • Kawaja, Michael David (Queen's University)
    Perturbing Sympathetic Hyperinnervation Associated with the Spontaneously Hypertensive Rat Phenotype
    2nd Year Award, Renewal, $65,256
     
  • Kearon, Clive (Henderson General Hospital)
    Fixed Dose unfractionated heparin for initial treatment of venous thromboembolism
    2nd Year Award, Renewal, $109,029
     
  • Kelton, John G. (McMaster University)
    Platelet-Mediated Acute Thrombocytopenic Disorders
    2nd Year Award, Renewal, $158,977
     
  • Koschinsky, Marlys L. (Queen's University)
    The Structural Basis of Lipoprotein (a) Pathogenicity
    2nd Year Award, Renewal, $78,709
     
  • Lafrenie, Robert M. (Northeastern Ont. Regional Cancer Ctre.)
    Integrin-dependent signal transduction in monocytes
    2nd Year Award, New Annual, $50,562
     
  • Langille, B. Lowell (The Toronto Hospital)
    Cell Biology of Atherosclerosis
    2nd Year Award, Program Grant, $154,195
     
  • Lee, Robert M.K. (McMaster University)
    Alterations in hypertensive arteries
    2nd Year Award, Renewal, $85,762
     
  • Lillicrap, David (Queen's University)
    The Influence of Genotype and Environment on von Willebrand Factor
    2nd Year Award, Renewal, $87,214
     
  • Lillicrap, David (Queen's University)
    The influence of genotype and environment on von Willebrand factor gene expression
    2nd Year Award, Career Investigator, $76,250
     
  • Liu, Peter P. (The Toronto General Hospital)
    Immunological Mechanisms of Chlamydia Induced Cardiovascular Injury
    2nd Year Award, New Annual, $101,197
     
  • MacDonald, John F. (University of Toronto)
    New Targets for ischemic Cell Death
    2nd Year Award, New Annual, $69,350
     
  • MacManus, John P. (National Research Council)
    E2F1 transcription factor and GAPDH promote neuronal death following cerebral ischemia
    2nd Year Award, Renewal, $59,241
     
  • Mak, Alan S. (Queen's University)
    The roles of Rho-GTPases in vascular smooth muscle cell migration
    2nd Year Award, Renewal, $77,861
     
  • Mantle, Ross E. (Loeb Health Research Institute)
    Functional characterization of hypothalamic and medullary synaptic inputs to spinal sympathetic preganglionic neurons
    2nd Year Award, Fellowship, $51,600
     
  • McKelvie, Robert S. (Hamilton Health Sciences Corporation)
    Assessing the Value of Screening for Asymptomatic Left Ventricular Dysfunction
    2nd Year Award, New Annual (Pending), $71,134
     
  • Megeney, Lynn A. (Ottawa General Hospital Research Inst.)
    Defining Molecular Basis for Post-natal Growth of the Myocardium
    2nd Year Award, New Annual, $75,174
     
  • Merino, Jose (London Health Science Centre)
    Advanced imaging of plaque instability in asymptomatic carotid stenosis
    2nd Year Award, Fellowship, $25,800
     
  • Mitchell, Lesley G. (The Hospital for Sick Children Res. Ins.)
    Predictors of thrombosis in patients with SLE and APLA: A prospective cohort study
    2nd Year Award, New Annual (Pending), $68,729
     
  • Monge, Juan C. (St. Michael's Hospital)
    Regulation of the Expression of the Endothelin Receptors
    2nd Year Award, New Annual, $68,760
     
  • Morley, Paul (NRC University of Ottawa)
    Mechanisms of Ischemic Preconditioning
    2nd Year Award, Renewal, $58,201
     
  • Morris, Catherine E. (Loeb Health Research Institute)
    Surface area Regulation: sublethal ischemia and neuronal repair
    2nd Year Award, Renewal, $47,854
     
  • Nag, Sukriti (The Toronto Hospital - Western Division)
    Regulation of Cerebrovascular Homeostasis and Repair by Angiogenic Factors
    2nd Year Award, New Annual, $64,333
     
  • Nakatsu, Kanji (Queen's University)
    Effects of nitrovasodilators, NO and CO on blood vessel function
    2nd Year Award, New Annual, $57,518
     
  • Nesheim, Michael E. (Queen's University)
    The Activation of TAFI and the Properties of TAFIa
    2nd Year Award, Renewal, $77,075
     
  • Nesheim, Michael E. (Queen's University)
    Collaborative Studies of Hemostatisis, Fibrinolysis and Vascular cell growth and function
    2nd Year Award, Program Grant, $126,131
     
  • Nichol, Graham (Loeb Health Research Institute)
    Clinical Outcomes Related to Economics for Congestive Heart Failure
    2nd Year Award, New Annual (Pending), $73,543
     
  • Noble, Earl (University of Western Ontario)
    Gender specific regulation of myocardial HSP 72: Molecular and functional implications
    2nd Year Award, New Annual, $31,442
     
  • O'Brien, Edward R. (University of Ottawa Heart Institute)
    Estrogen and Atherosclerosis 
    2nd Year Award, Renewal, $67,339
     
  • O'Brodovich, Hugh (Hospital for Sick Children)
    Pulmonary Edema's Effect on Epithelial Ion and Fluid Transport
    2nd Year Award, New Annual, $75,760
     
  • Ofosu, Frederick A. (McMaster University)
    Platelet-derived serine protease and platelet activation
    2nd Year Award, New Annual, $58,709
     
  • Parker, John D. (Mount Sinai Hospital)
    Endothelin-1 kinetics in human heart failure
    2nd Year Award, New Annual, $74,448
     
  • Pickering, J. Geoffrey (London Health Sciences Centre)
    Control of Smooth Muscle Cell Differentiation
    2nd Year Award, Renewal, $77,060
     
  • Pratt, M. Christine (University of Ottawa)
    Gender differences in vascular estrogen response: role of ERB
    2nd Year Award, Renewal, $73,038
     
  • Renaud, Leo P. (Ottawa Hospital)
    Suprachiasmatic Nucleus Efferents
    2nd Year Award, Renewal, $56,485
     
  • Ross, Gregory M. (Queen's University)
    A Zinc-Induced Loss of Neurotrophin Activity and Neuronal Death
    2nd Year Award, Renewal, $49,448
     
  • Serrador, Jorge M. (Hebrew Rehabilitation Ctr. for the Aged)
    Altered Baroreflex Modulation Effects on Cerebrovascular Regulation in Ageing and Disease
    2nd Year Award, Fellowship, $38,950
     
  • Shin, Seon H. (Queen's University)
    Mechanisms of ascorbate-induced brain cell death - a new stroke model
    2nd Year Award, New Annual, $57,755
     
  • Sibbald, William J. (Sunnybrook & Women's College Health Ctre)
    Mechanism and Consequences of Myocardial Tolerance in Sepsis
    2nd Year Award, Renewal, $60,054
     
  • Slack, Ruth (University of Ottawa)
    The Role of Bax and APAF1 in p53 Induced Neuronal Cell Death
    2nd Year Award, Renewal, $59,842
     
  • Sole, Michael J. (The Toronto General Hospital)
    Molecular Genetics of Hypertrophic Cardiomyopathy
    2nd Year Award, Renewal, $165,057
     
  • Sorisky, Alexander (Loeb Health Research Institute)
    PI 3-kinase-dependent signalling in the preadipocyte: differentiation, apoptosis, and obesity
    2nd Year Award, Career Investigator, $76,250
     
  • Sparks, Daniel L. (University of Ottawa Heart Institute)
    HDL Structure and Function
    2nd Year Award, Career Investigator, $76,250
     
  • Spence, J. David (John P. Robarts Research Institute)
    Determinants of carotid atherosclerosis: 1. Chlamydia and mannose binding lectin
    2nd Year Award, Renewal, $72,369
     
  • Stanimirovic, Danica B. (Inst. for Biological Sciences)
    Transcriptional Regulation of Inflammatory Genes in Brain Endothelial Cells and Astrocytes by Hypoxia/Ischemia
    2nd Year Award, Renewal, $56,541
     
  • Steiner, George (The Toronto General Hospital)
    Triglyceride-rich lipoprotein metabolism in insulin resistance and type 2 diabetes
    2nd Year Award, Renewal, $87,652
     
  • Tsushima, Robert G. (University of Toronto)
    Regulation of Cardiac Calcium-Activated Nonselective Cation Channels
    2nd Year Award, New Annual, $58,348
     
  • Tu, Jack V. (Inst. for Clinical Evaluative Sciences)
    Carotid Endarterectomy Health Services Research Program
    2nd Year Award, Renewal, $59,902
     
  • Verdi, Joseph M. (John P. Robarts Research Institute)
    PITS: A Novel Growth Arrest Gene in Sympathetic Neurogenesis
    2nd Year Award, New Annual, $61,255
     
  • Wan, Qi (Toronto Western Research Institute)
    Molecular mechanisms of AMPA receptor-mediated excitotoxicity
    2nd Year Award, New Annual, $69,680
     
  • Warkentin, Theodore E. (Hamilton Health Sciences Corporation)
    Heparin-induced thrombocytopenia
    2nd Year Award, Renewal, $61,397
     
  • Weaver, Lynne C. (John P. Robarts Research Institute)
    Cardiovascular control after spinal cord injury
    2nd Year Award, Renewal, $89,519
     
  • Wells, James W. (University of Toronto)
    Effects of G Proteins on Cardiac Muscarinic Receptors
    2nd Year Award, Renewal, $76,677
     
  • Wells, Philip S. (University of Ottawa)
    The Bioped Study
    2nd Year Award, Renewal, $41,640
     
  • Worton, Ronald D. (Ottawa General Hospital)
    Regulation of Dystrophin Expression in Cardiac & Skeletal Muscle
    2nd Year Award, New Annual, $54,968
     
  • Yao, Zemin (University of Ottawa Heart Institute)
    Functional analysis of HSPG ginding domains of human hepatic lipase
    2nd Year Award, New Annual, $45,474
     
  • Yeung, Rae S-M (Hospital for Sick Children)
    Kawasaki Disease: How a mouse becomes the vehicle of choice for studying coronary arteritis
    2nd Year Award, New Annual, $66,577
     
  • Yusuf, Salim (Hamilton General Hospital)
    Inter-Heart
    2nd Year Award, New Annual (Pending), $99,142

     

English