2017-2018 Grant-In-Aid Grantees

Accili, Eric (University of British Columbia)           
Control of pacemaker channel opening by cyclic nucleotides
Advani, Andrew (St. Michael's Hospital)             
Inflammation, epigenetics and heart failure in diabetes
Andelfinger, Gregor (Hôpital Sainte Justine)    
Role of Adamts19 in development and homeostasis of the aortic valve
Bagai, Akshay (St. Michael's Hospital)
Co-PI: Cheema, Asim             
ASSIST-MI CMR Trial: Revascularization Strategies for ST-Segment Elevation Myocardial Infarction Cardiac Magnetic Resonance
Beanlands, Rob (University of Ottawa Heart Institute)     
Bio-AIMI-HF Study: Role of Biomarkers in Optimizing Imaging Directed Management in Ischemic Heart Failure
Bolz, Steffen-Sebastian (University of Toronto)              
Circadian rhythms in the microcirculation govern cardiovascular homeostasis
Bonnet, Sébastien (Institut universitaire de cardiologie et de pneumologie de Québec)
Co-PI: Boucherat, Olivier       
Role of FOXM1 in DNA damage response and cell survival progression in pulmonary hypertension
Caldarone, Christopher (Hospital for Sick Children)         
Pilot Study: losartan therapy for pediatric patients with pulmonary vein stenosis
Cameron, Jill (University of Toronto)
Identifying Families' Needs during Palliative Care Post-Stroke: A Qualitative Study
Cepinskas, Gediminas (Lawson Health Research Institute)
Co-PI: Fraser, Douglas
Cerebrovascular endothelial cell and leukocyte inflammatory interaction: modulation by carbon monoxide-releasing molecules (CORMs)
Chih, Sharon (University of Ottawa Heart Institute)
Early Post Transplant Cardiac Allograft Vasculopathy: ECAV Phase I Study
Chilibeck, Philip (University of Saskatchewan)  
Endurance training and post-exercise low glycemic index recovery diet for improving postprandial triglycerides
Daskalopoulou, Styliani Stella (McGill University Health Center Research Institute)    
Modulation of the Adiponectin Receptor Pathway: a Novel Target for Carotid Atherosclerotic Plaque Stabilization
Delgado Olguin, Paul (Hospital for Sick Children)              
Epigenetic Regulation of Placental Vascular Development
Di Cristo, Graziella (Hôpital Sainte Justine)       
Mechanisms of GABAergic neuron vulnerability caused by perinatal asphyxia
Di Martino, Elena (University of Calgary)          
Bioengineering studies of aortic aneurysms
Dixon, Ian (University of Manitoba)    
Ski regulates Hippo signaling and ZEB2 in the fibrosed post-MI heart
Febbraio, Maria (University of Alberta)             
The Role Of Endothelial Cell CD36 in Metabolism & Cardiovascular Disease
Fedida, David (University of British Columbia)    
Biophysical properties and regulation of the IKs channel complex
Feng, Qingping (University of Western Ontario)
Sepsis therapy with annexin A5
Flamand, Louis (Centre Hospitalier Universitaire de Québec)            
Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases
Forkert, Nils Daniel (University of Calgary)       
Image-based predictive modelling of lesion evolution in acute ischemic stroke patients
Friedberg, Mark (Hospital for Sick Children)      
Heart Rate Reduction for Therapeutic Benefit in Pulmonary Arterial Hypertension
Gallagher, Anne (Hôpital Sainte Justine)           
Functional brain connectivity in infants with congenital heart disease (CHD): A predictor of neurodevelopmental outcomes
Gauthier, Claudine (Concordia University)        
Quantitative MRI of cerebral vascular, metabolic and microstructural health in cardiovascular disease
Gibson, William (University of British Columbia) 
Next-Generation Sequencing for Rare, Highly-Penetrant Mutations in Familial Intracranial Aneurysms
Gill, Sean (University of Western Ontario)          
The role of tissue inhibitors of metalloproteinases in microvascular endothelial cell activation and dysfunction during sepsis
Gilliland, Jason (University of Western Ontario)
Development and Evaluation of a Smartphone Based Program for Improving Food Literacy and Healthy Eating Among Youth
Goldstein, Benjamin (Sunnybrook Health Sciences Centre)             
Integrating Neurocognition and Inflammation with Retinal Vascular Photography among Adolescents at Increased Clinical and Familial Risk for Cardiovascular Disease
Gramolini, Anthony (University of Toronto)     
Regulation of phospholamban expression and activity in cardiac muscle
Grant, David (Toronto General Hospital)
Co-PI: Levy, Gary  
FGL2 and Heart Allotransplantation
Grewal, Jasmine (St. Paul's Hospital)
Co-PI: Levin, Adeera             
Chronic Kidney Damage in the Fontan Population
Griesdale, Donald (University of British Columbia)              
Cerebral oximetry to assess cerebral autoregulation in hypoxemic ischemic brain injury
Harris, Kevin (University of British Columbia)     
Physical activity and aortic stiffness in children with congenital heart disease
Hatch, Grant (University of Manitoba)
Regulation of cardiolipin biosynthesis in the heart
Jankov, Robert (Children's Hospital of Eastern Ontario)   
A novel approach to nitric oxide-based therapy for chronic neonatal lung injury and pulmonary hypertension
Johnson, James (University of British Columbia)               
Regulation of cardiomyocyte metabolism by partial Ryr2 loss
Jurasz, Paul (University of Alberta)    
Selective Angiostatin Neutralization for the Promotion of Therapeutic Angiogenesis
Kirshenbaum, Lorrie (University of Manitoba)  
Mechanisms of P53 Mediated Cell Death in the Heart
Koschinsky, Marlys (Robarts Research Institute)            
Role of oxidized phospholipid modification and lysine-binding properties of apo(a) in the pathogenicity of Lp(a)
Kriz, Jasna (Université Laval)              
Therapeutic reprogramming of microglia after stroke: identifying sex-dependent immune networks and targets
Lacoste, Baptiste (Ottawa Hospital Research Institute)   
Rho-kinase2 inhibition as an early intervention after ischemic stroke to modulate cerebrovascular plasticity and promote functional recovery
Lamarche-Vane, Nathalie (McGill University Health Center Research Institute)             
Molecular analysis of the Rac1/Cdc42 regulator CdGAP in post-natal angiogenesis and cardiac function
Lehner, Richard (University of Alberta)
Role of arylacetamide deacetylase (AADAC) in intestinal and hepatic lipoprotein production and atherosclerosis development
Little, Jonathan (University of British Columbia)
Impact of oral ketone supplements on cardiovascular risk factors
Lopaschuk, Gary (University of Alberta)           
Branched Chain Amino Acid Contribution to Cardiac Insulin Resistance in Heart Failure
Mann, Koren (Lady Davis Institute for Medical Research)  
Arsenic-enhanced atherosclerosis: the role of the macrophage
McGavock, Jonathan (University of Manitoba)
If you build it, with they come?... and live longer
McIntyre, Christopher (Lawson Health Research Institute)            
Reducing hemodialysis induced recurrent brain injury to improve patients’ lives
Mehta, Shamir (McMaster University)
STRIVE Pilot Trial: Adjunctive, low-dose intracoronary recombinant tissue plasminogen activator versus placebo for primary PCI in patients with ST-segment elevation myocardial infarction
Mielniczuk, Lisa (University of Ottawa Heart Institute)    
Spironolactone Therapy in Chronic Stable Right Heart Failure (STAR-HF) Trial
Murray, Allan (University of Alberta) 
Vascular repair in transplant vasculopathy
Nery, Pablo (University of Ottawa Heart Institute)
Co-PI: Redfearn, Damian       
Correlation Between Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation
Ni, Heyu (St. Michael's Hospital)           
The PSI domain of beta3 integrin: A novel mechanism and target for anti-thrombotic therapy
Nuyt, Anne Monique (Hôpital Sainte Justine)
Co-PI: Luu, Thuy Mai             
Exercise intervention to rescue the adverse effect of preterm birth on cardiovascular and pulmonary health
Oudit, Gavin (University of Alberta)    
Apelin Analogs as Novel Therapeutic Agents for Heart Failure
Ouimet, Mireille (University of Ottawa Heart Institute)    
Macrophage Lipophagy in Immunometabolism and Atherosclerosis
Patterson, Kara (Toronto Rehabilitation Institute)
Co-PI: Brooks, Dina
Dance for the improvement of balance and gait after stroke: A randomized controlled trial
Peng, Tianqing (Lawson Health Research Institute)          
Junctophilin-2 protects the heart against ischemia/reperfusion injury by preventing junctin degradation
Perreault, Sylvie (Université de Montréal)        
Effectiveness and safety of Direct Oral AntiCoagulants (DOACs) among older adults with atrial fibrillation
Pryzdial, Edward (University of British Columbia)              
Translating Novel Factor Xa Function to Treat Thrombosis
Rivard, Alain (Centre hospitalier de l'université de Montréal)            
Targeting Soluble Guanylate Cyclase to Improve Ischemia-Induced Neovascularization in Pathological Conditions
Saw, Jacqueline* (University of British Columbia)             
Canadian Spontaneous Coronary Artery Dissection Genetic Study
*Improving Heart Health for Women Award 2017 recipient
Sheehan, Kathleen (University of Toronto)
Co-PI: Kapral, Moira               
Quality of Care and Mortality Following Stroke for Individuals with Schizophrenia
Singh, Krishna (St. Michael's Hospital)
Novel Mechanisms in Cardiac Fibrosis and Heart Failure
Slack, Ruth (University of Ottawa)     
Regulation of Opa1 to maintain mitochondrial energy metabolism and survival after stroke
Stampfli, Martin (McMaster University)
Co-PI: Robbins, Clinton          
Relative importance of monocyte recruitment versus local macrophage proliferation in abdominal aortic aneurysms associated with cigarette smoke exposure
Szabo, Eva (McMaster University)       
Modeling endothelial dysfunction in early onset of cardiovascular artery disease (EOCAD) using patient specific induced pluripotent stem cell derived endothelial cells
Thebaud, Bernard Ottawa Hospital Research Institute)   
neoPerPHuse: Neonatal Pulmonary Exosome Rescue for Pulmonary Hypertension Using Superior Endothelial progenitor cells
Tijssen, Janice (Lawson Health Research Institute)          
Bystander CPR for Paediatric Out-of-Hospital Cardiac Arrest
Timmons, Brian (McMaster University)              
Longitudinal Cardiovascular Health AssessMent in Pediatric chronic Inflammatory conditiONs: role of physical activity and fitness (the CHAMPION-2 Study)
Ussher, John (University of Alberta)  
The Role of FoxO1 in the Pathology of Diabetic Cardiomyopathy
Verma, Atul (St. Michael's Hospital)
Co-PI: Ha, Andrew 
Post-Surgical Enhanced Monitoring for Cardiac Arrhythmias and Atrial Fibrillation (SEARCH-AF): A Randomized Controlled Trial
Vohl, Marie-Claude (Université Laval)               
DNA methylation-based determinants of obesity-related metabolic complications and improvements after bariatric surgery
Waisman, David (Dalhousie University)             
Defining the physiological function of S100A10 with the S100A10 knockout mouse
Werstuck, Geoffrey (McMaster University)       
Investigating the Effect of Hyperglycemia on the Vasa Vasorum: Is Accelerated Atherosclerosis a Microvascular Complication of Diabetes Mellitus
Zaugg, Michael (University of Alberta)              
Insulin resistance due to lipotoxicity of fat emulsions in healthy and diabetic hearts: underlying mechanisms and prevention
Zhang, Shetuan (Queen's University)
Identification of uremic toxin p-cresol-mediated hERG dysfunction as a mechanism for sudden cardiac death associated with chronic kidney disease