2015/16 Grant-In-Aid Grantees

Adeli, Khosrow (Hospital for Sick Children)
Mechanisms of Hepatic Steatosis and VLDL Overproduction in Insulin Resistance: Role of the Gut-Brain-Liver Axis
Afilalo, Jonathan (Sir Mortimer B. Davis Jewish General Hospital)
Optimal Revascularization Strategy in Patients Undergoing Aortic Valve Replacement
Alter, David (Institute for Clinical Evaluative Sciences)
The Efficacy of Personalized Audio-Playlists with Rhythmic Auditory Stimulation on Exercise Adherence in Cardiac Rehabilitation
Ambrose, Teresa (University of British Columbia)
Reshaping the Path of Vascular Cognitive Impairment with Resistance Training
Anand-Srivastava, Madhu (Université de Montréal)
Natriuretic peptide receptors in cardiovascular physiology and pathology
Austin, Richard (St. Joseph's Hospital – Hamilton)
Molecular and cellular basis of endoplasmic reticulum (ER) stress and its role in atherothrombotic disease
Beaudoin, Jonathan (Institut Universitaire de Cardiologie et de Pneumologie de Quebec)
Role and mechanisms of mitral leaflet remodelling in functional mitral regurgitation
Beique, Jean-Claude* (University of Ottawa)
Synaptic mechanisms in post-stroke depression
*awarded in partnership with the Brain Canada Foundation
Bendeck, Michelle (University of Toronto)
N-cadherin and Strategies to Inhibit Smooth Muscle Cell Migration
Bernatchez, Pascal (St. Paul's Hospital)
Aberrant endothelial mechano-sensing is a cause of early atherosclerosis and a pharmacological target
Boivin, Benoit (Montreal Heart Institute)
Understanding PTP1B regulation of microRNA-mediated gene silencing in cardiac hypertrophy
Bossé, Yohan (Institut universitaire de cardiologie et de pneumologie de Québec)
Multidimensional genomic profiling to elucidate the molecular mechanisms underpinning calcific aortic valve stenosis
Chauhan, Vijay (University Health Network)
Electrocardiographic evaluation of ventricular arrhythmia vulnerability in hypertrophic cardiomyopathy
Choy, Jonathan (Simon Fraser University)
Regulation of graft arteriosclerosis by IL-6
Claydon, Thomas (Simon Fraser University)
Molecular mechanisms of gating and drug binding in hERG cardiac potassium channels
Connelly, Kim (St. Michael's Hospital)
Identifying the role of silent information regulator (Sirt1) in ventricular remodeling using genetic ablation and pharmacological strategies.
Couet, Jacques (Institut universitaire de cardiologie et de pneumologie de Québec)
Modulating mTOR Activity in Aortic Stenosis.
Cregan, Sean* (University of Western Ontario)
Role of ATF4 and P53 family transcription factors in the regulation of neuronal cell death
*awarded in partnership with the Brain Canada Foundation
Dawson, John** (University of Guelph)
Hypertrophic Cardiomyopathy: Actin variants in the actomyosin interface.
**CP Has Heart Cardiovascular Award 2015 Recipient
Eikelboom, John** (McMaster University)
INTERBLEED-Pilot: a study of risk factors for GI bleeding and of cardiovascular outcomes after GI bleeding
**CP Has Heart Cardiovascular Award 2015 Recipient
Eng, Janice (University of British Columbia)
Use of a robotic exoskeleton to promote walking recovery after stroke
Epelman, Slava** (University Health Network)
Precise functional characterization of macrophage and dendritic cell subsets during viral myocarditis
**CP Has Heart Cardiovascular Award 2015 Recipient
Fedak, Paul (University of Calgary)
Epicardial Infarct Repair:  Defining Mechanisms to Optimize Therapy
Feldman, Ross (University of Western Ontario)
Estrogen regulation of vascular remodelling: role of GPER
Flynn, Lauren (University of Western Ontario)
Co-delivery of adipose-derived stem cells and SDF-1/HGF-1 in ligand grafted, in situ setting gels for the treatment of peripheral arterial disease
Garland, Allan (University of Manitoba)
Co-PI: Sanmartin, Claudia
Changes in Work and Earnings After Heart Attack and Stroke
Haas, Tara (York University)
Angiogenic regulators in peripheral limb ischemia
Hébert, Terence (McGill University)
Co-PI: Tanny, Jason
The role of the RNA polymerase II elongation complex in cardiac hypertrophy and heart disease.
Hegele, Robert (Robarts Research Institute)
Genomics and phenomics of hypertriglyceridemia and cardiometabolic syndrome
Heximer, Scott (University of Toronto)
Defining novel mechanisms in the pathogenesis of bradyarrhythmias and sick sinus node syndrome.
Kassner, Andrea (Hospital for Sick Children)
Co-PI: Narang, Indra
MRI assessment of cerebral vascular injury in obese children with obstructive sleep apnea
Khan, Zia (University of Western Ontario)
Regulation of vascular stem cell differentiation and plasticity
Kubes, Paul** (University of Calgary)
Role of Platelets in Sterile and Infectious Perturbations
**CP Has Heart Cardiovascular Award 2015 Recipient
Kutryk, Michael (St. Michael's Hospital)
Surface modification of implantable materials for novel therapeutic applications
Lagace, Thomas (Ottawa Heart Institute)
Regulation of the PCSK9 binding interaction with LDL receptor
Le Gal, Gregoire** (Ottawa Hospital Research Institute)
Age-adjusted D-dimer cutoff levels to rule out deep vein thrombosis (The ADJUST-DVT Study)
**CP Has Heart Cardiovascular Award 2015 Recipient
Lewis, Gary (Toronto General Hospital Research Institute)
CNS-mediated effects of insulin and GLP-1 on intestinal and hepatic lipoprotein particle production in humans
Li, Ren-Ke (University Health Network)
A New Growth Factor, CNPY2, To Induce Angiogenesis after Cardiac Ischemia
Lok, Charmaine (Toronto General Hospital)
PISCES-Pilot: Protection against Incidences of Cardiovascular Events Study with Daily Fish Oil Supplementation in Dialysis Patients - Pilot Study in Satellite Dialysis
Marette, Andre (Institut universitaire de cardiologie et de pneumologie de Québec)
Cardioprotective action of PDX in obese diabetic mice
Martino, Tami (University of Guelph)
Role of CLOCK in Heart Disease
McAlister, Finlay (University of Alberta)
Exploring the interplay between renal function and outcomes in non-valvular atrial fibrillation
Mequanint, Kibret (University of Western Ontario)
Engineered human vascular tissues as platforms for preclinical testing
Nattel, Stanley (Montreal Heart Institute)
Molecular Control of Cardiac Repolarization and the Substrate for Lethal Ventricular Arrhythmias
Ni, Heyu (St. Michael's Hospital)
Apolipoprotein A-IV and platelet function: Novel links with thrombosis, inflammation, and atherosclerosis
Pare, Guillaume (McMaster University)
Genetic determinants of early stroke – A population study from INTERSTROKE
Parent, Lucie (Institut de Cardiologie de Montréal)
Unraveling the complex interactions between the auxiliary Cavα2δ subunit and the cardiac L-type calcium channel
Park, David* (University of Ottawa)
Mechanisms of delayed death in Stroke
*awarded in partnership with the Brain Canada Foundation
Pasumarthi, Kishore (Dalhousie University)
Molecular and functional characterization of cardiac progenitor cells
Robertson, George* (Dalhousie University)
Mitochondrial calcium uptake and targeted therapeutics
*awarded in partnership with the Brain Canada Foundation
Sanatani, Shubhayan** (BC Children's Hospital)
Understanding the risk of sudden death in families: cascade screening in CPVT
**CP Has Heart Cardiovascular Award 2015 Recipient
Schmolzer, Georg (Royal Alexandra Hospital)
Novel Resuscitation Techniques to Improve the Recovery of Asphyxiated Newborns
Schulz, Richard** (University of Alberta)
Matrix metalloproteinase-2 at the myocardial endoplasmic reticulum/mitochondrial interface in cardiac ischemia/reperfusion injury
**CP Has Heart Cardiovascular Award 2015 Recipient
Sharpe, Simon (Hospital for Sick Children)
Co-PI: Pomes, Regis
Linking structural and functional consequences of sequence polymorphisms in human tropoelastin with susceptibility to late-onset vascular diseases
Sheffield, William (McMaster University Medical Centre)
Targeting factor XIa for improved antithrombotic therapy
Shrier, Alvin (McGill University)
Co-PI: Glass, Leon
Transition to tachycardia
Simmons, Craig** (University of Toronto)
Co-PI: Yau, Terrence
The roles of C-type natriuretic peptide in aortic valve disease
**CP Has Heart Cardiovascular Award 2015 Recipient
Teasell, Robert (Lawson Health Research Institute)
A temporal analysis of stroke rehabilitation evidence
Thanassoulis, George (McGill University Health Center Research Institute)
The lipoprotein(a), oxidized phospholipid and lipoprotein-associated phospholipase A2 pathway in Aortic Valve Calcification
Thiruganasambandamoorthy, Venkatesh (Ottawa Hospital Research Institute)
Risk Stratification of Adult Emergency Department Syncope Patients to Predict Short-Term Serious Adverse Events after Discharge (RiSEDS study) Phase II
Thorin, Eric (Montreal Heart Institute)
Pulse pressure-dependent regulation of cerebrovascular endothelial function through age and cardiovascular diseases
Tremblay, Mark (Children's Hospital of Eastern Ontario)
Co-PI: Larouche, Richard
Active transportation, independent mobility, and physical activity among school children: a multi-site study
Trigatti, Bernardo (McMaster University)
Role of the multisubunit adaptor protein, PDZK1, in leukocytes in atherosclerosis development and HDL induced plaque regression
Tulloch, Heather (Ottawa Heart Institute)
Co-PI: Collins, Barbara
Neurocognitive Outcomes after Out-of-Hospital Cardiac Arrest
Udell, Jacob** (Women's College Hospital)
Co-PI: Redelmeier, Donald
Investigation of Notable Failed Endeavours at Reproductive Treatment and Ischemic Long-term Events (INFERTILE) Study
**CP Has Heart Cardiovascular Award 2015 Recipient
Wen, Shi Wu** (Ottawa Hospital Research Institute)
Congenital heart disease in infants born to mothers conceived by assisted reproductive technology: a record linkage study with Ontario registries
**CP Has Heart Cardiovascular Award 2015 Recipient
West, Lori (University of Alberta)
ABO-incompatible heart transplantation: pathways to tolerance
Woods, Michael* (Memorial University of Newfoundland)
Identification of novel genes causing intracranial aneurysms
*awarded in partnership with the Brain Canada Foundation